生物能源与过程高端论坛

报告题目：Synthetic Biology of Acetogenic Bacteria for Sustainable C1 gas bioconversion

报  告  人：Byung-Kwan Cho 教授，韩国科学技术院（KAIST）

主  持  人：徐健 研究员

报告时间：2026年1月13日（周二）下午13:30-14:30

报告地点：新源路园区214会议室

报告人简介：

Prof. Cho serves as a KAIST Endowed Chair Professor and Vice President of the Office of Research Affairs at the Korea Advanced Institute of Science and Technology (KAIST). Prior to joining KAIST, he worked as a project scientist in the Department of Bioengineering at the University of California San Diego, USA. He earned his Ph.D. from Seoul National University, Korea, specializing in molecular biotechnology and biomaterials. Current research initiatives include engineering microorganisms using information-rich datasets and synthetic biology tools for four main applications: developing C1 biorefinery systems using acetogens, constructing minimal genome E. coli chassis platform, discovering secondary metabolites from Streptomycetes, and designing therapeutic microbes. As of January 2026, his scientific contributions include 240 published articles and 30 registered patents with h-index 62. His achievements have been recognized through several prestigious appointments, including KAIST Endowed Chair Professor (2021), World Top 2% Scientist by Elsevier (2024), and young scientist by both the World Economic Forum (2012) and the Korea Academy of Science and Technology (2013).

报告摘要：

The C1 gases generated in various industrial processes mainly consist of carbon dioxide (CO₂) and carbon monoxide (CO). Acetogens have emerged as biocatalysts for recycling C1 gases by converting them into value-added biochemicals using the Wood-Ljungdahl (WL) pathway, the most efficient natural CO₂-fixation pathway. However, despite the advantage of applying acetogens as biocatalysts, most previous studies have focused on understanding the biochemistry of the WL pathway and the physiological changes of several model acetogen strains due to the lack of knowledge about the genetic landscape under C1-autotrophic conditions. To overcome those limitations, we have considered understanding the C1 fixation mechanism in acetogens at the molecular level based on systems biology. Next, using genetic information, we constructed several genetic bio-parts and modules based on synthetic biology for controlling metabolic flux in acetogens. Finally, to develop highly efficient C1 conversion biocatalysts, we introduced several value-added biochemical pathways into the acetogen and produced those chemicals using C1 gas fermentation.

欢迎感兴趣的老师、同学参加！请提前10分钟入场！